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''Making a flat leaf: Pre-patterning, morphogenic small RNAs, and Turing reactions''

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Thursday 12 December 2019, 11:00 - 12:30


Khoa Nguyen1, Emanuele Scacchi1, Agata Burian2, Gael Paszkiewicz1, and Marja Timmermans1


1) Center for Plant Molecular Biology, University of Tuebingen, Auf der Morgenstelle 32, 72076 Tuebingen, Germany

2) University of Silesia in Katowice, Jagiellonska 28, 40-032 Katowice, Poland


Development of flat leaf architecture posses an unusual and mechanistically challenging problem; namely, how to create a stable adaxial-abaxial (top-bottom) boundary within the plane of a long and wide, but shallow, structure. The acquisition and maintenance of this polar axis involves an intricate gene regulatory network with several highly conserved transcription factors that promote either adaxial or abaxial fate at its core. These are expressed in complementary domains delineating the top and bottom side of the initiating organ, respectively.  The positional information needed to define these domains is provided in part by small RNAs that, reminiscent to classical morphogens, generate sharply defined domains of target gene expression through an intrinsic and direct threshold-based readout of their mobility gradients. While the polarity network is sufficient to cleanly separate regions of adaxial and abaxial identity, our most recent findings from mathematical modeling predict that additional inputs are needed to maintain a robust, uniformly positioned developmental boundary. Interestingly, anisotropic growth is one such input. The maintenance of a stable adaxial-abaxial boundary during primordium growth may thus rely on the anisotropic nature of that growth.

Location Jozef Schell Seminar Room
Contact Prof Marja Timmermans
University of Tuebingen
Center for Plant Molecular Biology