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"Bromodomains are essential for the functions of SWI/SNF complex in Arabidopsis"

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Thursday 24 January 2019, 11:00 - 12:30


SWI/SNF chromatin remodelers are evolutionary conserved, multi-protein complexes, which use the energy of ATP hydrolysis to change histone - DNA interactions. SWI/SNF complexes are composed of a catalytic ATPase subunit, and other evolutionary conserved subunits. Some SWI/SNF subunits including ATPase contain bromodomains, which are assumed to contribute to SWI/SNF targeting through the interactions with acetylated histones. However, the importance of bromodomains for SWI/SNF functions is currently not clear. We characterised bromodomain-containing non-catalytic SWI/SNF subunits (BRDs) in Arabidopsis and found that they are involved in regulation of various processes including leaf development, flowering, and hormonal responses. Genetic analyses and protein interaction studies indicate that three BRD proteins are dedicated to SWI/SNF complexes and that bromodomains present in BRDs and the ATPase subunit BRM are together essential for the SWI/SNF activity.

Location Jozef Schell Seminar Room
Contact Dr Rafal Archacki
Laboratory of Systems Biology
University of Warsaw and IBB PAS